The best Side of cees dekker
The best Side of cees dekker
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Employing single-molecule optical and AFM imaging and force-spectroscopy procedures, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our investigate interests include things like:
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, Groningen researchers current the outcome of their initiatives for making labs extra sustainable and supply tips for other labs.
Due to the fact 2000, Dekker has shifted the primary emphasis of his do the job in the direction of biophysics wherever he studies the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, as well as through the prolonged-time period standpoint that many intriguing discoveries might be predicted During this field.[5] Present lines of analysis in his biophysics group are while in the parts of:[six]
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SMC complexes can move physical roadblocks larger than their ring sizing, indicating a nontopological system for DNA loop extrusion
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which assess the fundamental function of spatial confinement in the molecular and cellular level. Our jobs involve the subsequent:
2000, discovery that nanotubes can have remarkable substantial present densities; solved the controversial difficulty of electronic transport by DNA molecules by measurements of insulating behavior at The only molecule level; and demonstration of an AFM procedure for one-molecule manipulation of nanotubes
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Right now, we also recognized that it should be feasible to utilize just one semiconducting carbon nanotube to create a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and utilised the fundamental silicon substrate being a gate electrode, developing the basic three-terminal structure of the discipline-result transistor (Fig.
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Cees Dekker is Distinguished University Professor at TU Delft. Educated like a physicist, he pioneered nanotechnology with a lot of discoveries on carbon nanotubes while in the nineties. Considering that 2000, he moved to solitary-molecule biophysics and nanobiology. His recent investigation concentrates on (i) nanopores for protein sequencing; (ii) chromosome construction, particularly SMC motor protein; and (iii) building a dwelling artificial mobile from lifeless molecules. Dekker is undoubtedly an elected member on the KNAW and fellow on the APS along with the IOP.
As an example, we look at the nucleopore complex, a gateway concerning the cell nucleus as well as the cytoplasm. This is a very sophisticated process and so hard to study inside of a cell, so we use biomimetics. We reconstruct holes and after that insert unique things on the nucleopore complicated to check transport through it at The only-molecule level.’
Reliable-condition nanopores have demonstrated being a shockingly versatile probe for one-molecule analysis of DNA. I'll explain many of our the latest conclusions – specially DNA knots – and our endeavours to develop the abilities of reliable-point out nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.